HLAhuman leukocyte antigen

High resolution genotyping of HLA class I and class II genes using ScisGo-HLA

ScisGo-HLA-v6 is a next generation sequencing (NGS) technology that yields high resolution genotypes for all eleven HLA-class I (CI) and class II (CII) loci. The NGS data cover all exon and sufficient intron sequences to yield 3-field typing with detection of all known null alleles. Ambiguities are minimized with zero allele ambiguities and rare diploid ambiguities encountered at the 3-field HLA allele level. We offer range of standard and customized data reporting options.

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Sample HLA Report

KIRKiller Ig-Like Receptor

KIR haplotype and allele typing with ScisGo-KIR-v3

ScisGo-KIR-v3 is a system that allows for the determination of gene copy number and haplotype as well as targeted KIR gene allele determination. Gene copy number is determined by comparisons of amplicon-derived read numbers between distinct KIR exon/loci. Haplotypes are deduced from gene copy number according to established reference haplotypes.

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Sample KIR Report

MICABMHC Class I chain-related A & B

High resolution genotyping of the MICA and MICB genes using ScisGo-MICAB-v3

ScisGo-MICAB-v3 is a next generation sequencing (NGS) technology that yields high resolution genotypes for MICA and MICB. The NGS data cover all exon and sufficient intron sequences to yield 2-field typing for all loci including the detection of all known null alleles.

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Sample MICAB Report

FcR-IGHGFc receptor + Immunoglobulin heavy G

High resolution genotyping of FcR and IGHG for diagnostics and therapeutics with ScisGo-FcR/IGHG-v2

ScisGo-FcR-IGHG technology utilizes existing data sets at the IMGT and the NCBI genbank repository supplemented with long range sequencing of 1000 genome samples from 25 populations providing a comprehensive database of FcR and IGHG polymorphism. This enhanced database allows the majority of variants detected by the short-read NGS assay to be phased accordingly through mapping back to the database. Our current targeting probes for the FcR genes include a panel of variants that have been previously characterized functionally. The four IgG encoding genes are targeted at the CH1, CH2 and CH3 regions

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Sample FcR-IGHG Report